Description
What it is
A mitochondrial-derived peptide that signals from mitochondria to the rest of the cell — discovered in 2015 and now one of the most active areas in longevity research.
Why it’s studied
MOTS-C represents an entirely new class of signaling molecules. Research has focused on metabolic regulation, insulin sensitivity, and exercise capacity — with effects that mimic exercise at the cellular level.
Key research findings
-
Improved insulin sensitivity in diet-induced obesity models (Lee et al., Cell Metabolism)
-
Increased running endurance in animal exercise studies
-
Documented activation of AMPK and metabolic gene expression pathways
