Description
What it is
A small-molecule inhibitor of NNMT (nicotinamide N-methyltransferase) — an enzyme upregulated in obese adipose tissue and linked to metabolic dysfunction.
Why it’s studied
5-Amino-1MQ is one of the few compounds in metabolic research that targets adipose tissue directly via NNMT inhibition — a mechanism distinct from every GLP-1 or GHRH compound.
Key research findings
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Significant fat mass reduction without changes to food intake (Neelakantan et al., diet-induced obesity model)
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Preserved muscle mass during fat loss in animal models
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Documented NNMT inhibition restoring NAD+ and SAM cellular pools
