Description
What it is
A tripeptide fragment of alpha-MSH (Lysine-Proline-Valine), studied extensively for anti-inflammatory effects in skin and gut barrier research.
Why it’s studied
KPV modulates inflammatory pathways without immunosuppression — a mechanism distinct from traditional anti-inflammatory compounds. Research has focused on inflammatory bowel models and skin barrier integrity.
Key research findings
-
Downregulation of TNF-α and IL-6 in inflammatory bowel research (Kannengiesser et al.)
-
Improved gut barrier integrity in colitis animal models
-
Demonstrated anti-inflammatory effects in skin tissue research
